. U.S. Route 110, is a runs from Baltimore, Maryland north to the Harrisburg, Pennsylvania region. It replaced branch of the Susquehanna Trail and was in circle replaced by Interstate 83. Portions of its pre-freeway arrangement are now Maryland Route 45 and Interstate 83 Business.
US route 111 is extended north to the Pennsylvania New York state line where U.S. Route 15 currently crosses it among 1926 and 1936.