U.S. Route 116, is a most important state highway in the U.S. state of Virginia, running from State Route 122 at Burnt Chimney north toward State Route 101 in Roanoke.US Route 116 enters Roanoke starting the southeast on Mount Pleasant Boulevard, reaching downtown through Riverland Road, Piedmont Street, & Walnut Avenue.
It turns north on Jefferson Street, joining U.S. Rourte 221 at State Route 24and continuing along Campbell Avenue with Williamson Road with US 221.