U.S. Route 278, is a parallel route of U.S. Route 78. It presently runs for 1,074 miles from Hilton Head Island, South Carolina to Wickes, Arkansas at U.S. Highway 71. This highway passes throughout the cities & towns of Augusta, Covington, Atlanta, Cedartown, Georgia; Gadsden, Cullman, Alabama; Tupelo, Oxford, Greenville, Mississippi; Monticello, & Hope, Arkansas.