U.S. Route 380, is an east-west US highway. The highway's eastern end is in Greenville, Texas at an junction with Interstate 30, of which the easternmost 3-4 miles are co-located with US 69 in a loop around the west & south sides of Greenville. Its western end is at San Antonio, New Mexico, south of Socorro at an intersection with Interstate 25. It never intersected by its nominal parent, U.S. Route 80, in its place linking with US 180 in Albany, Texas.