. U.S. Route 42, an east-west United States highway that runs towards northeast-southwest for about 355 miles (571 km) from Cleveland, Ohio towards Louisville, Kentucky.
. This route has several names which include Pearl Road from Cleveland towards Medina in Northeast Ohio, the Cincinnati as well as Lebanon Pike in southwestern Ohio as well as Brownsboro Road inside Louisville, Kentucky.
. The highway's eastern end is in Downtown Cleveland, Ohio and its western terminus is in Louisville (Kentucky).
. This road has been largely replaced by I-71 during the early 1960s.