U.S. Route 622, is an urge route of U.S. Route 22 in the eastern U. S. It is having the length of 308 miles. It passes through the states of Virginia, West Virginia, Maryland, & Pennsylvania. The southern end of the route is at U.S. Route 60 in Powhatan, Virginia. The northern end is at U.S. Route 11 and U.S. Route 15 in Selinsgrove, Pennsylvania.