Truck drivers and driver/sales workers held about 3.4 million jobs in 2006. Of these workers, 445,000 were driver/sales workers and 2.9 million were truck drivers. Most truck drivers find employment in large metropolitan areas or along major interstate roadways where trucking, retail, and wholesale companies tend to have their distribution outlets. Some drivers work in rural areas, providing specialized services such as delivering newspapers to customers.

The truck transportation industry employed 26 percent of all truck drivers and driver/sales workers in the United States. Another 25 percent worked for companies engaged in wholesale or retail trade. The remaining truck drivers and driver/sales workers were distributed across many industries, including construction and manufacturing.

Around 9 percent of all truck drivers and driver/sales workers were self-employed. Of these, a significant number were owner-operators who either served a variety of businesses independently or leased their services and trucks to a trucking company.